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Q: Where does chaga come from and why are birch trees so important?
A: Wild birch trees grow in northern climates...

Q: What is so special about chaga?
A: It is a dense powerhouse of 215 potent and unique phyto-nutrients...

Q: What is superoxide dismutase?
A:  SOD is an antioxidant enzyme needed by the entire body. SOD is the main antioxidant...

Q: What are the benefits of chaga in a daily diet?
A:  There are many benefits to the use of chaga. Commonly, it is used as a daily tonic...

Q:  Is chaga safe?
A:  Yes. Chaga is completely natural and there have been no reported side-effects...

Below you will find the most compelling research investigations into the benefits and possible medical applications for chaga. Click on the title of the study and the abstract for the study will be displayed courtesy of PubMed. Here you can learn what the medical community believes the future holds for the powerful chaga mushroom.

Separation of an aqueous extract Inonotus obliquus (Chaga). A novel look at the efficiency of its influence on proliferation of A549 human lung carcinoma cells.

Mazurkiewicz W, Rydel K, Pogocki D, Lemieszek MK, Langner E, Rzeski W.

Acta Pol Pharm. 2010 Jul-Aug;67(4):397-406.PMID: 20635536 [PubMed - indexed for MEDLINE

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells.

Chung MJ, Chung CK, Jeong Y, Ham SS.

Nutr Res Pract. 2010 Jun;4(3):177-82. Epub 2010 Jun 29.PMID: 20607061 [PubMed - in process]Free PMC ArticleFree text

Optimization of hydroxyl radical scavenging activity of exo-polysaccharides from Inonotus obliquus in submerged fermentation using response surface methodology.

Chen H, Xu X, Zhu Y.

J Microbiol Biotechnol. 2010 Apr;20(4):835-43.PMID: 20467262 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Phytochemical characteristics and hypoglycaemic activity of fraction from mushroom Inonotus obliquus.

Lu X, Chen H, Dong P, Fu L, Zhang X.

J Sci Food Agric. 2010 Jan 30;90(2):276-80.PMID: 20355042 [PubMed - indexed for MEDLINE]Related citations

Anti-inflammatory effects of Inonotus obliquus in colitis induced by dextran sodium sulfate.

Choi SY, Hur SJ, An CS, Jeon YH, Jeoung YJ, Bak JP, Lim BO.

J Biomed Biotechnol. 2010;2010:943516. Epub 2010 Mar 10. Review.PMID: 20300439 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Cancer cell cytotoxicity of extracts and small phenolic compounds from Chaga [Inonotus obliquus (persoon) Pilat].

Nakajima Y, Nishida H, Matsugo S, Konishi T.

J Med Food. 2009 Jun;12(3):501-7.PMID: 19627197 [PubMed - indexed for MEDLINE]Related citations

Antioxidant activities of extracts and subfractions from Inonotus Obliquus.

Liang L, Zhang Z, Wang H.

Int J Food Sci Nutr. 2009;60 Suppl 2:175-84. Epub 2009 Jul 1.PMID: 19585318 [PubMed - in process]Related citations

Anti-inflammatory effect of Inonotus obliquus, Polygala senega L., and Viburnum trilobum in a cell screening assay.

Van Q, Nayak BN, Reimer M, Jones PJ, Fulcher RG, Rempel CB.

J Ethnopharmacol. 2009 Sep 25;125(3):487-93. Epub 2009 Jul 3.PMID: 19577624 [PubMed - indexed for MEDLINE]Related citations

Progress of research on Inonotus obliquus.

Zhong XH, Ren K, Lu SJ, Yang SY, Sun DZ.

Chin J Integr Med. 2009 Apr;15(2):156-60. Epub 2009 Apr 29. Review.PMID: 19407959 [PubMed - indexed for MEDLINE]Related citations

Antitumor activity of water extract of a mushroom, Inonotus obliquus, against HT-29 human colon cancer cells.

Lee SH, Hwang HS, Yun JW.

Phytother Res. 2009 Dec;23(12):1784-9.PMID: 19367670 [PubMed - indexed for MEDLINE]Related citations

Oxidative stress response of Inonotus obliquus induced by hydrogen peroxide.

Zheng W, Zhao Y, Zhang M, Wei Z, Miao K, Sun W.

Med Mycol. 2009 Dec;47(8):814-23.PMID: 19184774 [PubMed - in process]Related citations

Comparative study of antioxidant activity and antiproliferative effect of hot water and ethanol extracts from the mushroom Inonotus obliquus.

Hu H, Zhang Z, Lei Z, Yang Y, Sugiura N.

J Biosci Bioeng. 2009 Jan;107(1):42-8.PMID: 19147108 [PubMed - indexed for MEDLINE]Related citations

Evaluation of antitumor activity of peptide extracts from medicinal plants on the model of transplanted breast cancer in CBRB-Rb(8.17)1Iem mice.

Tepkeeva II, Moiseeva EV, Chaadaeva AV, Zhavoronkova EV, Kessler YV, Semushina SG, Demushkin VP.

Bull Exp Biol Med. 2008 Apr;145(4):464-6.PMID: 19110595 [PubMed - indexed for MEDLINE]Related citations

Potential anticancer properties of the water extract of Inonotus [corrected] obliquus by induction of apoptosis in melanoma B16-F10 cells.

Youn MJ, Kim JK, Park SY, Kim Y, Park C, Kim ES, Park KI, So HS, Park R.

J Ethnopharmacol. 2009 Jan 21;121(2):221-8. Epub 2008 Oct 25.PMID: 19041933 [PubMed - indexed for MEDLINE]Related citations

Inotodiol, a lanostane triterpenoid, from Inonotus obliquus inhibits cell proliferation through caspase-3-dependent apoptosis.

Nomura M, Takahashi T, Uesugi A, Tanaka R, Kobayashi S.

Anticancer Res. 2008 Sep-Oct;28(5A):2691-6.PMID: 19035296 [PubMed - indexed for MEDLINE]Related citations

Antimutagenic effects of subfractions of Chaga mushroom (Inonotus obliquus) extract.

Ham SS, Kim SH, Moon SY, Chung MJ, Cui CB, Han EK, Chung CK, Choe M.

Mutat Res. 2009 Jan 10;672(1):55-9. Epub 2008 Oct 17.PMID: 18992843 [PubMed - in process]Related citations

Identification of Inonotus obliquus and analysis of antioxidation and antitumor activities of polysaccharides.

Song Y, Hui J, Kou W, Xin R, Jia F, Wang N, Hu F, Zhang H, Liu H.

Curr Microbiol. 2008 Nov;57(5):454-62. Epub 2008 Sep 16.PMID: 18795365 [PubMed - indexed for MEDLINE]Related citations

Lanostane-type triterpenoids from the sclerotia of Inonotus obliquus possessing anti-tumor promoting activity.

Taji S, Yamada T, Wada S, Tokuda H, Sakuma K, Tanaka R.

Eur J Med Chem. 2008 Nov;43(11):2373-9. Epub 2008 Feb 8.PMID: 18387711 [PubMed - indexed for MEDLINE]Related citations

Chaga mushroom (Inonotus obliquus) induces G0/G1 arrest and apoptosis in human hepatoma HepG2 cells.

Youn MJ, Kim JK, Park SY, Kim Y, Kim SJ, Lee JS, Chai KY, Kim HJ, Cui MX, So HS, Kim KY, Park R.

World J Gastroenterol. 2008 Jan 28;14(4):511-7.PMID: 18203281 [PubMed - indexed for MEDLINE]Free PMC ArticleFree textRelated citations

Identification of a novel blocker of IkappaBalpha kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-kappaB.

Sung B, Pandey MK, Nakajima Y, Nishida H, Konishi T, Chaturvedi MM, Aggarwal BB.

Mol Cancer Ther. 2008 Jan;7(1):191-201.PMID: 18202022 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

New antioxidant polyphenols from the medicinal mushroom Inonotus obliquus.

Lee IK, Kim YS, Jang YW, Jung JY, Yun BS.

Bioorg Med Chem Lett. 2007 Dec 15;17(24):6678-81. Epub 2007 Oct 25.PMID: 17980585 [PubMed - indexed for MEDLINE]Related citations

Antioxidant small phenolic ingredients in Inonotus obliquus (persoon) Pilat (Chaga).

Nakajima Y, Sato Y, Konishi T.

Chem Pharm Bull (Tokyo). 2007 Aug;55(8):1222-6.PMID: 17666849 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Analysis of aqueous extract of Inonotus obliquus.

Mazurkiewicz W.

Acta Pol Pharm. 2006 Nov-Dec;63(6):497-501.PMID: 17438866 [PubMed - indexed for MEDLINE]Related citations

Isolation and characterization of a novel platelet aggregation inhibitory peptide from the medicinal mushroom, Inonotus obliquus.

Hyun KW, Jeong SC, Lee DH, Park JS, Lee JS.

Peptides. 2006 Jun;27(6):1173-8. Epub 2005 Nov 11.PMID: 16289471 [PubMed - indexed for MEDLINE]Related citations

Chaga mushroom extract inhibits oxidative DNA damage in human lymphocytes as assessed by comet assay.

Park YK, Lee HB, Jeon EJ, Jung HS, Kang MH.

Biofactors. 2004;21(1-4):109-12.PMID: 15630179 [PubMed - indexed for MEDLINE]Related citations

Antioxidant effect of Inonotus obliquus.

Cui Y, Kim DS, Park KC.

J Ethnopharmacol. 2005 Jan 4;96(1-2):79-85.PMID: 15588653 [PubMed - indexed for MEDLINE]Related citations

Biologically active compounds from Aphyllophorales (polypore) fungi.

Zjawiony JK.

J Nat Prod. 2004 Feb;67(2):300-10. Review.PMID: 14987072 [PubMed - indexed for MEDLINE]Related citations

[The nature of melanin pigments from some micro- and macromycetes]

Babitskaia VG, Shcherba VV.

Prikl Biokhim Mikrobiol. 2002 May-Jun;38(3):286-91. Russian. PMID: 12068581 [PubMed - indexed for MEDLINE]Related citations

[Physicochemical properties of melanins produced by Inonotus obliquus("chagi") in the nature and the cultivated fungus]

Kukulianskaia TA, Kurchenko NV, Kurchenko VP, Babitskaia VG.

Prikl Biokhim Mikrobiol. 2002 Jan-Feb;38(1):68-72. Russian. PMID: 11852571 [PubMed - indexed for MEDLINE]Related citations

[Melanin complex of the fungus Inonotus obliquus]

Babitskaia VG, Shcherba VV, Ikonnikova NV.

Prikl Biokhim Mikrobiol. 2000 Jul-Aug;36(4):439-44. Russian. PMID: 10994193 [PubMed - indexed for MEDLINE]Related citations

[Effects of bioglycans from birch fungus Inonotus obliquus on the electrical activity of cells from the cardiac venous sinus of the frog]

Golovko VA.

Biull Eksp Biol Med. 1999 Sep;128(9):264-6. Russian. No abstract available. PMID: 10560041 [PubMed - indexed for MEDLINE]Related citations

The effect of aqueous extracts from Inonotus obliquus on the mitotic index and enzyme activities.

Rzymowska J.

Boll Chim Farm. 1998 Jan;137(1):13-5.PMID: 9595828 [PubMed - indexed for MEDLINE]Related citations

Antimitotic activity of aqueous extracts of Inonotus obliquus.

Burczyk J, Gawron A, Slotwinska M, Smietana B, Terminska K.

Boll Chim Farm. 1996 May;135(5):306-9.PMID: 8942059 [PubMed - indexed for MEDLINE]Related citations

Fungi in Khanty folk medicine.

Saar M.

J Ethnopharmacol. 1991 Feb;31(2):175-9.PMID: 2023426 [PubMed - indexed for MEDLINE]Related citations

Effect of the extracts from fungus Inonotus obliquus on catalase level in HeLa and nocardia cells.

Jarosz A, Skórska M, Rzymowska J, Kochmańska-Rdest J, Malarczyk E.

Acta Biochim Pol. 1990;37(1):149-51.PMID: 2087905 [PubMed - indexed for MEDLINE]Free ArticleRelated citations

Antitumor Activity of Triterpenes in Inonotus obliquus.

Kahlos K, Kangas L, Hiltunen R.

Planta Med. 1986 Dec;52(6):554. No abstract available. PMID: 17345522 [PubMed - in process]Related citation

[Aqueous extracts of Inonotus obliquus vel. Poria obliqua in the diagnosis of leukemias.]

KRAUSS-ZAKI J.

Postepy Hig Med Dosw. 1962 Sep-Oct;16:855-9. Polish. No abstract available. PMID: 14035596 [PubMed - indexed for MEDLINE]Related citations

[Nature and origin of water-soluble pigment complex formed by Inonotus obliquus.]

SHIVRINA AN, LOVIAGINA EV, PLATONOVA EG.

Biokhimiia. 1959 Jan-Feb;24(1):67-72. Russian. No abstract available. PMID: 13628806 [PubMed - indexed for MEDLINE]Related citations

[Pharmacological and biological characteristics of Inonotus obliquus.]

BAZYLEVA NN, BOLOTKINA LI, LASKINA EM, OSVETIMSKAIA NP, SMIRNOVA LI.

Farmakol Toksikol. 1958 Sep-Oct;21(5):89-90. Russian. No abstract available. PMID: 13609697 [PubMed - OLDMEDLINE]Related citations

 
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